Should I come out at work?

sofosbuvir has come out of the magic box

Should health care come with a warranty?

How health care providers get paid has implications for the delivery of care and cost control; the topic is especially important during an economic downturn with persistent growth in health spending. Adding "warranties" to care is an innovation that transfers risk to providers, because payment includes allowances for defects. How do such warranties affect patient care and bottom lines? We exami...

A True Work - in - Progress . I Have Sketched Out

A panoply of retailer practices, such as advertising loss leaders or marketing house brands, take advantage of third party trademarks to increase the retailer’s profit. In a sense, trademark owners create spillover benefits for these retailers (I call these benefits “brand spillovers”). This Article examines the phenomenon and legal treatment of brand spillovers. In general, retailers have not ...

Get out! And don't come back!

sing the immune system to attack cancers is a good idea, but it may only work if Toll-like receptors (TLRs) are activated to break tolerance, say Yiping Yang (Duke University, Durham, NC), Drew Pardoll (Johns Hopkins, Baltimore, MD), and colleagues. The favored method for delivering cancer immunotherapy has been dendritic cells: they are the central antigen-presenting cells for generating T cel...

Sorting out where fibroblasts come from.

H eart failure is the primary cause of adult mortality in the Western world, affecting 1% to 2% of the population, including ≤10% of people >70 1. Several disease settings, including coronary artery disease, hypertension, diabetes melli-tus, and hypertrophic cardiomyopathy, promote a maladaptive response characterized by myocyte hypertrophy and fibrosis. The latter refers to excessive extracell...